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Highly Accessed Review

The properties and applications of single-molecule DNA sequencing

John F Thompson* and Patrice M Milos

Author affiliations

Helicos BioSciences Corporation, Building 200LL, One Kendall Square, Cambridge, MA 02139, USA

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Citation and License

Genome Biology 2011, 12:217  doi:10.1186/gb-2011-12-2-217

Published: 24 February 2011

Abstract

Single-molecule sequencing enables DNA or RNA to be sequenced directly from biological samples, making it well-suited for diagnostic and clinical applications. Here we review the properties and applications of this rapidly evolving and promising technology.