Additional file 9.

Mutual information between expression and pairwise histone modification signals. For each pair of histone modifications (denoted as H1, H2), the heat map shows the normalized mutual information I(E, H1 AND H2)/max(I(E,H1),I(E,H2)). For pairs such as H3K4me2 and K4K36me3, the combination of two features gives a higher predictive power than the two individual features.

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Cheng et al. Genome Biology 2011 12:R15   doi:10.1186/gb-2011-12-2-r15