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Dating the age of admixture via wavelet transform analysis of genome-wide data

Irina Pugach1*, Rostislav Matveyev2, Andreas Wollstein34, Manfred Kayser4 and Mark Stoneking1

Author Affiliations

1 Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, Germany

2 Institute for Mathematics, University of Leipzig, PF 10 09 20, Leipzig, D-04009, Germany

3 Cologne Center for Genomics, University of Cologne, Weyertal 115b, Cologne, D-50931, Germany

4 Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Postbus 2040, Rotterdam, 3000 CA, The Netherlands

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Genome Biology 2011, 12:R19 doi:10.1186/gb-2011-12-2-r19

Published: 25 February 2011

Abstract

We describe a PCA-based genome scan approach to analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavelet transform method with simulations and apply it to genome-wide SNP data from eight admixed human populations. The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species.