Performance of Hapmix and wavelet transform analysis in recovering the average number of recombination breakpoints per Morgan of genetic distance from simulated data. The two methods were applied to 20 artificially admixed individuals, created using a genomewide average of 20% European and 80% African ancestry. For simulated data the average number of ancestry switches (or breakpoints) was drawn from an exponential distribution with weight λ, such that the ancestry switch occurred with the probability 1 - e-λg for each distance of g Morgans. The following values of λ were simulated: 6, 10, 20, 40, 60, 100, 200, 400. Since in the simulated genomes the true number of breakpoints is known, we show the accuracy of both methods in recovering this information.
Pugach et al. Genome Biology 2011 12:R19 doi:10.1186/gb-2011-12-2-r19