The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics
1 Department of Genetics, 77 Ave. of Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA
2 Wyss Institute for Biologically - Inspired Engineering, 3 Blackfan Circle, Boston, MA 02115, USA
3 Department of Computer Science, Yale University, 51 Prospect St, New Haven, CT 06511, USA
4 Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Ave, New Haven, CT 06511, USA
5 Department of Genetics, Stanford University School of Medicine, Alway M344, Stanford, CA 94305, USA
6 Program in Computational Biology and Bioinformatics, Yale University, 266 Whitney Ave, New Haven, CT 06511, USA
Genome Biology 2011, 12:R32 doi:10.1186/gb-2011-12-3-r32Published: 31 March 2011
Additional file 1:
Supplementary materials. Further description of methods in the text and results of synthetic cross patterns.
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Additional file 2:
Table of TF-target properties. Full listing of transcription factor and gene target properties from the regulatory network example.
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Additional file 3:
Table of SMILES. 291 small molecules and their SMILE representations.
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Additional file 4:
Table of molecular descriptors index. Index of all molecular descriptors calculated (only six used in main text).
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Additional file 5:
Table of molecular descriptors values. The values for all the molecular descriptors calculated (only six used in the main text).
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Additional file 6:
Table of sensitivity scores for each drug-protein treatment. Listing of the sensitivity score for each protein for each of the six molecular descriptors used in the text.
Format: TXT Size: 56KB Download file