Plots of DP-sensitive proteins. The x-axis is the growth defect score of the particular protein after treatment with a small molecule and the y-axis is the density plot. The purple region shows the overlap between the two distributions. The smaller this overlap the more 'sensitive' the protein is to the value of the particular drug property. (a) YGL084C or GUP1 is involved in glycerol uptake. Treatment with drugs with a low partition coefficient have a significantly larger fitness defect (P < 0.0001). (b) YAL010C (MDM10) is involved in importing and assembling beta barrel proteins. It is significantly more disrupted by drugs with fewer aromatic bonds (P < 0.01). (c) YAL008W or FUN14 is a mitochondrial protein of unknown function. It is disrupted more by low molecular weight drugs (P < 0.02).
Gianoulis et al. Genome Biology 2011 12:R32 doi:10.1186/gb-2011-12-3-r32