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Highly Accessed Opinion

What does biologically meaningful mean? A perspective on gene regulatory network validation

Albertha JM Walhout

Author affiliations

Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA

Citation and License

Genome Biology 2011, 12:109  doi:10.1186/gb-2011-12-4-109

Published: 11 April 2011

Abstract

Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.