Opinion
What does biologically meaningful mean? A perspective on gene regulatory network validation
Author affiliations
Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Citation and License
Genome Biology 2011, 12:109 doi:10.1186/gb-2011-12-4-109
Published: 11 April 2011Abstract
Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.
