The constraints used in  to find biologically meaningful solutions and the ratios of success percentages between the original network and random networks. (a) The transcriptional regulatory structure of a convergence mode with two regulators (R1 and R2) and n target genes (G1, G2..., Gn). (b) The equations of introducing constraints used in . The symbol tri indicates the time when the corresponding regulator i starts to function. Ci represents the conversion efficiency of the regulator i. Ci,j and tri,j indicate the values used for the regulator i and the target gene j. 'min' in equation (v) means the minimal value. (c) The ratio of the success percentage at each corresponding threshold in a relatively high score range (≥ 13) between the original network and random networks. This panel was generated using the same data as used for Figure 2b of .
Ye et al. Genome Biology 2011 12:404 doi:10.1186/gb-2011-12-4-404