Additional file 1.
Supplementary Figures S1 to S3. Figure S1: pptimal probe melting temperature is consistent in exons, introns, and intergenic regions. Mean Dscore is plotted by probe melting temperature in exons, introns, and intergenic regions; vertical lines indicate 95% confidence intervals. Probes with approximately 66°C melting temperature consistently provided the best performance. Figure S2: CGH data reproducibility. CGH scatterplots for individual CNV events are displayed for replicate hybridizations from independent labeling reactions demonstrating data reproducibility. CNV events from three separate parasite clones are displayed: (a) Dd2; (b) HB3; (c) SC05. The CNV breakpoints are precisely identified between hybridizations. Figure S3: CNV detection in a WGA field sample. CGH scatterplot for a CNV event detected in a WGA field sample, M1064. Four genes (PFE1150w, PFE1155c, PFE1160w, and PFE1165c) are affected by this CNV, including the P. falciparum multidrug resistance gene, pfmdr1.
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Tan et al. Genome Biology 2011 12:R35 doi:10.1186/gb-2011-12-4-r35