Schematic overview of the copy-number analysis framework. High-level overview of our cancer copy-number analysis framework, highlighting specific differences between the original GISTIC algorithm  and the GISTIC 2.0 pipeline described in this manuscript. The first step, accurate identification of the copy-number profile in each sample, is common to GISTIC and GISTIC2.0.
Mermel et al. Genome Biology 2011 12:R41 doi:10.1186/gb-2011-12-4-r41