Sensitivity of peel-off to detect secondary driver events. The average fraction of secondary driver events recovered in independent (not containing the primary driver) peaks by GISTIC using the standard peel-off method (blue line) or arbitrated peel-off (red line) is shown for two simulated datasets. (a) The data are derived from 1,000 simulated chromosomes across 300 samples with a primary driver event present in 10% of samples and a secondary driver event a fixed distance away that is present in 5% of samples. (b) Data are derived from 10,000 simulated chromosomes across 300 samples with a primary driver event present in 10% of samples and a secondary driver event present in 5% of samples, where the fraction of the secondary driver events that overlapped with the primary driver event was varied between 100% (complete dependence; far left) and 0% (complete independence; far right). Error bars represent the mean ± standard error of the mean (some are too small to be visible).
Mermel et al. Genome Biology 2011 12:R41 doi:10.1186/gb-2011-12-4-r41