Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Review

Mapping of disease-associated variants in admixed populations

Daniel Shriner*, Adebowale Adeyemo, Edward Ramos, Guanjie Chen and Charles N Rotimi*

Author Affiliations

Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA

For all author emails, please log on.

Genome Biology 2011, 12:223  doi:10.1186/gb-2011-12-5-223

Published: 30 May 2011

Abstract

Recent developments in high-throughput genotyping and whole-genome sequencing will enhance the identification of disease loci in admixed populations. We discuss how a more refined estimation of ancestry benefits both admixture mapping and association mapping, making disease loci identification in admixed populations more powerful.

High-throughput genotyping and sequencing will enable refined estimation of ancestry, thus enhancing disease loci identification in admixed populations