Mapping of disease-associated variants in admixed populations
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
Genome Biology 2011, 12:223 doi:10.1186/gb-2011-12-5-223Published: 30 May 2011
Recent developments in high-throughput genotyping and whole-genome sequencing will enhance the identification of disease loci in admixed populations. We discuss how a more refined estimation of ancestry benefits both admixture mapping and association mapping, making disease loci identification in admixed populations more powerful.
High-throughput genotyping and sequencing will enable refined estimation of ancestry, thus enhancing disease loci identification in admixed populations