Figure 4.

Chromatin accessibility patterns at developmentally dynamic elements. Developmentally dynamic elements (DDEs; see text for definition) were clustered according to quantitative accessibility patterns, and ordered according to the time of peak accessibility. (a) Number of DDEs in each cluster. (b) Average accessibility at each stage for all regions within the cluster. Each row in panels (a) and (b) represents a distinct cluster (n = 65). (c) Selected clusters from (b), which are expanded to the resolution of individual elements, wherein each pixel row depicts DNaseI sensitivity (raw tag density, highest in yellow) in a 10-kb window around each DDE in the cluster.