Table 1

Nominally significant (P < 0.05) gene expression correlations with cellular sensitivity to chemotherapeutic agents

Gene

Drug

P-value

Chromosome


AKT1S1

Carboplatin

0.04497

19

AKT1S1

Daunorubicin

0.01149

19

AKT1S1

Etoposide

0.00610

19

ALKBH8

Daunorubicin

0.01151

11

AMY1A

Etoposide

0.03933

1

AMY2A

Etoposide

0.03933

1

ANKLE1

Carboplatin

0.03017

19

ANKLE1

Daunorubicin

0.01706

19

ANKRD36B

Daunorubicin

0.02380

2

BCLAF1

Daunorubicin

0.01498

6

C13orf3

Carboplatin

0.00830

13

C13orf3

Cisplatin

0.01980

13

C13orf3

Daunorubicin

0.00572

13

C18orf1

Cisplatin

0.00398

18

CAB39L

Etoposide

0.04179

13

DIS3L2

Daunorubicin

0.03077

2

DNAJC5

Carboplatin

0.00166

20

DNAJC5

Cisplatin

0.04058

20

FBRS

Carboplatin

0.00661

16

FGFR4

Carboplatin

0.00556

5

FKBP14

Carboplatin

0.03912

7

FLI1

Carboplatin

0.04735

11

FLI1

Daunorubicin

0.00314

11

FLI1

Etoposide

0.04230

11

GALNT1

Daunorubicin

0.00065

18

GPR107

Etoposide

0.00674

9

GPR137

Carboplatin

0.00616

11

GPR137

Cisplatin

0.00828

11

GPR137

Etoposide

0.01493

11

GPR144

Etoposide

0.04526

9

GSPT1

Carboplatin

0.04002

16

GSPT1

Cisplatin

0.01429

16

HLA-DQA1

Daunorubicin

0.00946

6

HLA-DQA1

Etoposide

0.00022

6

IGLV3-21

Carboplatin

0.04800

22

MOXD1

Carboplatin

0.00002

6

MOXD1

Cisplatin

0.00002

6

MOXD1

Daunorubicin

0.03454

6

MOXD1

Etoposide

0.00007

6

MTA1

Etoposide

0.01401

14

NCOA1

Daunorubicin

0.04278

2

NEK6

Carboplatin

0.04050

9

NUB1

Etoposide

0.02671

7

PPP1R3B

Cisplatin

0.03039

8

PTP4A2

Carboplatin

0.01930

1

PTP4A2

Cisplatin

0.01182

1

PTP4A2

Etoposide

0.03348

1

RCC1

Carboplatin

0.01252

1

RCC1

Cisplatin

0.01722

1

RCC1

Daunorubicin

0.00002

1

RCC1

Etoposide

0.01358

1

RNF103

Daunorubicin

0.02655

2

RPN2

Daunorubicin

0.01206

20

SLC10A7

Daunorubicin

0.00481

4

SLC4A8

Cisplatin

0.02189

12

SLC4A8

Etoposide

0.00248

12

SMPD4

Daunorubicin

0.02446

2

SNRK

Carboplatin

0.00396

3

SNRK

Cisplatin

0.00479

3

SNRK

Daunorubicin

0.02429

3

SULF2

Carboplatin

0.00002

20

SULF2

Cisplatin

0.00053

20

SULF2

Daunorubicin

0.00014

20

SULF2

Etoposide

0.00000

20

TBC1D22A

Cisplatin

0.03807

22

TBL1XR1

Carboplatin

0.04028

3

TFDP1

Cisplatin

0.04967

13

TNK2

Carboplatin

0.01901

3

TNK2

Daunorubicin

0.00431

3

TNK2

Etoposide

0.01159

3

TYRO3

Etoposide

0.02840

15

UPK3B

Cisplatin

0.02839

7

WDR90

Daunorubicin

0.02575

16

WDR90

Etoposide

0.00111

16

ZDHHC4

Daunorubicin

0.02463

7

ZFAND2A

Daunorubicin

0.00227

7

ZFAND2A

Etoposide

0.03567

7

ZNF277

Etoposide

0.04521

7

ZNF331

Carboplatin

0.02122

19

ZNF664

Carboplatin

0.04722

12


Transcripts are cis-regulated by CNVs identified from whole-genome sequencing.

Gamazon et al. Genome Biology 2011 12:R46   doi:10.1186/gb-2011-12-5-r46

Open Data