Table 1 |
|||
|
Nominally significant (P < 0.05) gene expression correlations with cellular sensitivity to chemotherapeutic agents |
|||
|
Gene |
Drug |
P-value |
Chromosome |
|
|
|||
|
AKT1S1 |
Carboplatin |
0.04497 |
19 |
|
AKT1S1 |
Daunorubicin |
0.01149 |
19 |
|
AKT1S1 |
Etoposide |
0.00610 |
19 |
|
ALKBH8 |
Daunorubicin |
0.01151 |
11 |
|
AMY1A |
Etoposide |
0.03933 |
1 |
|
AMY2A |
Etoposide |
0.03933 |
1 |
|
ANKLE1 |
Carboplatin |
0.03017 |
19 |
|
ANKLE1 |
Daunorubicin |
0.01706 |
19 |
|
ANKRD36B |
Daunorubicin |
0.02380 |
2 |
|
BCLAF1 |
Daunorubicin |
0.01498 |
6 |
|
C13orf3 |
Carboplatin |
0.00830 |
13 |
|
C13orf3 |
Cisplatin |
0.01980 |
13 |
|
C13orf3 |
Daunorubicin |
0.00572 |
13 |
|
C18orf1 |
Cisplatin |
0.00398 |
18 |
|
CAB39L |
Etoposide |
0.04179 |
13 |
|
DIS3L2 |
Daunorubicin |
0.03077 |
2 |
|
DNAJC5 |
Carboplatin |
0.00166 |
20 |
|
DNAJC5 |
Cisplatin |
0.04058 |
20 |
|
FBRS |
Carboplatin |
0.00661 |
16 |
|
FGFR4 |
Carboplatin |
0.00556 |
5 |
|
FKBP14 |
Carboplatin |
0.03912 |
7 |
|
FLI1 |
Carboplatin |
0.04735 |
11 |
|
FLI1 |
Daunorubicin |
0.00314 |
11 |
|
FLI1 |
Etoposide |
0.04230 |
11 |
|
GALNT1 |
Daunorubicin |
0.00065 |
18 |
|
GPR107 |
Etoposide |
0.00674 |
9 |
|
GPR137 |
Carboplatin |
0.00616 |
11 |
|
GPR137 |
Cisplatin |
0.00828 |
11 |
|
GPR137 |
Etoposide |
0.01493 |
11 |
|
GPR144 |
Etoposide |
0.04526 |
9 |
|
GSPT1 |
Carboplatin |
0.04002 |
16 |
|
GSPT1 |
Cisplatin |
0.01429 |
16 |
|
HLA-DQA1 |
Daunorubicin |
0.00946 |
6 |
|
HLA-DQA1 |
Etoposide |
0.00022 |
6 |
|
IGLV3-21 |
Carboplatin |
0.04800 |
22 |
|
MOXD1 |
Carboplatin |
0.00002 |
6 |
|
MOXD1 |
Cisplatin |
0.00002 |
6 |
|
MOXD1 |
Daunorubicin |
0.03454 |
6 |
|
MOXD1 |
Etoposide |
0.00007 |
6 |
|
MTA1 |
Etoposide |
0.01401 |
14 |
|
NCOA1 |
Daunorubicin |
0.04278 |
2 |
|
NEK6 |
Carboplatin |
0.04050 |
9 |
|
NUB1 |
Etoposide |
0.02671 |
7 |
|
PPP1R3B |
Cisplatin |
0.03039 |
8 |
|
PTP4A2 |
Carboplatin |
0.01930 |
1 |
|
PTP4A2 |
Cisplatin |
0.01182 |
1 |
|
PTP4A2 |
Etoposide |
0.03348 |
1 |
|
RCC1 |
Carboplatin |
0.01252 |
1 |
|
RCC1 |
Cisplatin |
0.01722 |
1 |
|
RCC1 |
Daunorubicin |
0.00002 |
1 |
|
RCC1 |
Etoposide |
0.01358 |
1 |
|
RNF103 |
Daunorubicin |
0.02655 |
2 |
|
RPN2 |
Daunorubicin |
0.01206 |
20 |
|
SLC10A7 |
Daunorubicin |
0.00481 |
4 |
|
SLC4A8 |
Cisplatin |
0.02189 |
12 |
|
SLC4A8 |
Etoposide |
0.00248 |
12 |
|
SMPD4 |
Daunorubicin |
0.02446 |
2 |
|
SNRK |
Carboplatin |
0.00396 |
3 |
|
SNRK |
Cisplatin |
0.00479 |
3 |
|
SNRK |
Daunorubicin |
0.02429 |
3 |
|
SULF2 |
Carboplatin |
0.00002 |
20 |
|
SULF2 |
Cisplatin |
0.00053 |
20 |
|
SULF2 |
Daunorubicin |
0.00014 |
20 |
|
SULF2 |
Etoposide |
0.00000 |
20 |
|
TBC1D22A |
Cisplatin |
0.03807 |
22 |
|
TBL1XR1 |
Carboplatin |
0.04028 |
3 |
|
TFDP1 |
Cisplatin |
0.04967 |
13 |
|
TNK2 |
Carboplatin |
0.01901 |
3 |
|
TNK2 |
Daunorubicin |
0.00431 |
3 |
|
TNK2 |
Etoposide |
0.01159 |
3 |
|
TYRO3 |
Etoposide |
0.02840 |
15 |
|
UPK3B |
Cisplatin |
0.02839 |
7 |
|
WDR90 |
Daunorubicin |
0.02575 |
16 |
|
WDR90 |
Etoposide |
0.00111 |
16 |
|
ZDHHC4 |
Daunorubicin |
0.02463 |
7 |
|
ZFAND2A |
Daunorubicin |
0.00227 |
7 |
|
ZFAND2A |
Etoposide |
0.03567 |
7 |
|
ZNF277 |
Etoposide |
0.04521 |
7 |
|
ZNF331 |
Carboplatin |
0.02122 |
19 |
|
ZNF664 |
Carboplatin |
0.04722 |
12 |
|
|
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|
Transcripts are cis-regulated by CNVs identified from whole-genome sequencing. |
|||
|
Gamazon et al. Genome Biology 2011 12:R46 doi:10.1186/gb-2011-12-5-r46 |
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