Table 2

Resources generated from large-scale mouse genetics projects

Resource

Web site

Description

Reference


Australian Phenomics Network

http://www.australianphenomics.org.au webcite

Provides resources and services for producing, screening and archiving mutant mice

Canadian Mouse Mutant Repository

http://www.cmmr.ca/ webcite

Archived ES cells, sperm, ova, embryos, and DNA

Cancer Models Database

http://cancermodels.nci.nih.gov webcite

A database of mouse lines that model the genesis, progression or clinical course of human cancers

Center for Animal Resources and Development

http://cardb.cc.kumamoto-u.ac.jp/transgenic webcite

A repository of over 1,300 mutant lines

Centre for Modeling Human Disease

http://www.cmhd.ca/databases webcite

ENU mutagenesis and gene trap databases

Collaborative Cross

http://mouse.ornl.gov/projects/collabcross.html webcite

A resource for the genetic analysis of complex traits

[110]

Cre-X-mice

http://nagy.mshri.on.ca webcite

A Cre-expressing transgenic mouse line database

[44]

CreZoo

http://bioit.fleming.gr/crezoo webcite

A Cre-expressing transgenic mouse line database

Ensembl

http://www.ensembl.org webcite

A genome database for mouse and other eukaryotes

[111]

European Conditional Mouse Mutagenesis Program

http://www.eucomm.org webcite

Aims to generate and distribute a collection of 13,000 mutated ES cell lines using conditional approaches

[112]

European Mouse Disease Clinic

http://www.eumodic.org webcite

Aims to generate phenome data on 650 knockout mice generated by the EUCOMM project

[82]

European Mouse Mutant Archive

http://www.emmanet.org webcite

A European repository with over 1,700 mutant strains

[113]

European Mouse Phenotyping Resource for Standardized Screens (EMPReSS)

http://empress.har.mrc.ac.uk webcite

A primary screening platform with over 100 standard operating procedures validated on inbred strains

[81]

European Union Mouse Research for Public Health and Industrial Applications

http://www.eumorphia.org webcite

Novel approaches in phenotyping, mutagenesis and informatics to improve the characterization of mouse models

[114]

EuroPhenome

http://www.europhenome.org webcite

A database to hold phenome data from EMPReSS

[115]

Federation of International Mouse Resources

http://www.fimre.org webcite

Coordinates repositories and resource centers globally

[116]

GenomeSpace

http://www.genomespace.org webcite

A central workspace for genomics tools, including Galaxy, Integrative Genomics Viewer and UCSC Browser

Heterogeneous Stock Phenotyping Project

http://mus.well.ox.ac.uk/mouse/HS webcite

A searchable map of QTLs that contribute to variation in over 100 complex traits, using Heterogeneous Stock mice

[88]

International Gene Trap Consortium

http://www.genetrap.org webcite

Information on >380,000 gene-trapped ES cell lines

[117]

International Knockout Mouse Consortium

http://www.komp.org/ikmc webcite

Aims to minimize overlap, share resources, and improve services among the three major knockout projects

[79]

Knockout Mouse Project

http://www.knockoutmouse.org webcite

Aims to target 8,500 genes and make mice available to the community

[4]

MouseBook

http://www.mousebook.org webcite

MRC Harwell's mouse resources; includes a frozen embryo and sperm archive, an ENU screen and DNA archive, and standardized phenotyping procedures

[118]

Mouse Genome Database

http://www.informatics.jax.org webcite

Provides integrated genetic, genomic, and biological data on laboratory mouse strains

[119]

Mouse Genomes Project

http://www.sanger.ac.uk/resources webcite

Raw sequence data, SNPs and assemblies of 17 mouse genomes

Mouse Phenome Project

http://phenome.jax.org webcite

A collection of baseline phenotypic data on commonly used inbred mouse strains

[83]

Mouse Resources Portal

http://www.sanger.ac.uk/mouseportal webcite

The Sanger Institute's resources; includes available BACs, gene targeting vectors, ES cells and mutant mouse lines with associated phenotypic data

[10]

Mutant Mouse Regional Resource Centers

http://www.mmrrc.org webcite

A repository of mouse stocks and ES cell lines

North American Conditional Mouse Mutagenesis project

http://www.norcomm.org webcite

Aims to target >2,000 genes that have not been previously targeted or trapped

[4]

PB Mutagenesis Information Center

http://www.idmshanghai.cn/PBmice webcite

A database for storing, retrieving and displaying information derived from PB transposon insertions

[120]

RIKEN Bioresource Center

http://www.brc.riken.jp/lab/animal/en webcite

A Japanese repository of live and archived lines


van der Weyden et al. Genome Biology 2011 12:224   doi:10.1186/gb-2011-12-6-224