Figure 1.

High resolution map of hydroxymethylcytosine in human embryonic stem cells. (a) Genome-browser view of hmeDIP-seq data. Two hmeDIP-seq datasets along with input DNA and 'no antibody' controls are shown. Each track is represented as normalized density of reads (reads/bp/million uniquely mapping reads). (b) Gene density (genes/bp) and 5hmC peak density (peaks/bp) in chromosome 3. (c) 5hmC over genes with different expression levels. 5hmC peak density was plotted over RefSeq genes in 300-bp bins. Plots were smoothed by taking the moving average over ± 2 bins. Published RNA sequencing data [9] were used to rank the genes. TSS, transcription start site; TTS, transcription termination site.