Additional file 13.

Figure S8 - genotyping receiver operating characteristic curves for simulated data sets. Receiver operating characteristic (ROC)-style curves are shown reporting SNP identification performance on four synthetic genomic DNA templates (RPL, 2 × RPL + 2%, 2 × RPL + 5%, 2 × RPL + 10%). Five unknown sample genomes were generated from each reference template by adding SNPs randomly to a proportion of 0.001. Read sets were sampled from each sample genome to one of nine coverage levels (4-fold, 10-fold, 25-fold, 32-fold, 50-fold, 75-fold, 100-fold, 150-fold, 200-fold). Read sets were independently aligned to their respective reference genome using ALL, UNI, or BEST maps with k = 1, 2, or 3 mismatches and genotyped using Sniper. Plots show the number of false positive SNPs plus the number of calls with no read coverage versus sensitivity.

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Simola and Kim Genome Biology 2011 12:R55   doi:10.1186/gb-2011-12-6-r55