Additional file 1.

Additional materials and methods and Additional Tables. Detailed methods describing technicalities of the database integration and algorithms, with the following sections. Knowledge integration: detecting hub nodes by computing a priori probabilities with random walks; computing a posteriori probabilities and ranking relations; backtracking heuristic for the automated generation of functional hypotheses; additional results. Additional Table 1: top 50 hubs or highest ranking concepts of the computation of the a priori rank score in the integrated network. Additional Table 2: area under the receiver operator characteristic (ROC) curve (AUC) for the prioritization of disease genes in the Endeavour benchmark. Additional Table 3: effect on the Endeavour benchmark after leaving out each separate database from the data integration process.

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Liekens et al. Genome Biology 2011 12:R57   doi:10.1186/gb-2011-12-6-r57