Table 2 |
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Top inferred genes for schizophrenia |
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|
Number |
Gene |
Prioritization hypothesis |
SZ association studies |
|
|
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|
1 |
PRL |
Affected by the antipsychotics aripiprazole and risperidone, neuroactive ligand-receptor interaction, associated with autistic disorder |
No association studies. Associated with autistic disorder [16] |
|
2 |
ARID4B |
Target of mir-20b |
No association studies |
|
3 |
HTR1A |
Related to HTR2A |
Positive association [19] |
|
4 |
DRD2 |
Related to DRD3 |
Positive association [20] |
|
5 |
DNMT3B |
Target of mir-29*, related to COMT, folic acid |
Positive association [21] |
|
6 |
DNMT3A |
Target of mir-29*, related to COMT, folic acid |
No association studies |
|
7 |
FSTL1 |
Target of mir-206 |
No association studies |
|
8 |
SYN3 |
Related to SYN2 |
No association found [23] |
|
9 |
MYLIP |
Target of mir-20b, involved in CNS development |
No association studies |
|
10 |
EFEMP2 |
Target of mir-346 |
No association studies |
|
11 |
UTRN |
Interacts with DISC1, target of mir-206 |
No association studies |
|
12 |
OMG |
Myelin sheet, interacts with RTN4R, axonogenesis |
Weak positive association [22]. Putatively associated with mental retardation [38] |
|
13 |
BACE1 |
Target of mir-29*, Alzheimer's disease |
No association studies. Schizophrenia-like phenotypes in BACE1-null mice [39] |
|
14 |
HIPK3 |
Target of mir-20b |
No association studies |
|
15 |
TAC1 |
Target of mir-206, axonal and synaptic transmission |
No association studies. Down-regulated in psychosis [40] |
|
16 |
ATXN1 |
Interacts with ZNF804A and AKT1 |
Positive association [18] |
|
17 |
SYN1 |
Related to SYN2 |
No association studies. Associated with epilepsy [41] |
|
18 |
RTN4IP1 |
Interacts with RTN4R, neurite growth |
No association studies |
|
19 |
CDKN1A |
Interacts with AKT1, target of mir-20b |
No association studies |
|
20 |
LINGO1 |
Interacts with RTN4R, axonogenesis, CNS development |
No association studies. Associated with essential tremor and Parkinson's disease [42] |
|
|
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|
BioGraph top inferred genes for schizophrenia that are not known as direct relations in the integrated network. Prioritizations are based on a data freeze of September 2009 to retrospectively verify predictions in more recent literature. CNS, central nervous system. |
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Liekens et al. Genome Biology 2011 12:R57 doi:10.1186/gb-2011-12-6-r57 |
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