Table 2

Top inferred genes for schizophrenia

Number

Gene

Prioritization hypothesis

SZ association studies


1

PRL

Affected by the antipsychotics aripiprazole and risperidone, neuroactive ligand-receptor interaction, associated with autistic disorder

No association studies. Associated with autistic disorder [16]

2

ARID4B

Target of mir-20b

No association studies

3

HTR1A

Related to HTR2A

Positive association [19]

4

DRD2

Related to DRD3

Positive association [20]

5

DNMT3B

Target of mir-29*, related to COMT, folic acid

Positive association [21]

6

DNMT3A

Target of mir-29*, related to COMT, folic acid

No association studies

7

FSTL1

Target of mir-206

No association studies

8

SYN3

Related to SYN2

No association found [23]

9

MYLIP

Target of mir-20b, involved in CNS development

No association studies

10

EFEMP2

Target of mir-346

No association studies

11

UTRN

Interacts with DISC1, target of mir-206

No association studies

12

OMG

Myelin sheet, interacts with RTN4R, axonogenesis

Weak positive association [22]. Putatively associated with mental retardation [38]

13

BACE1

Target of mir-29*, Alzheimer's disease

No association studies. Schizophrenia-like phenotypes in BACE1-null mice [39]

14

HIPK3

Target of mir-20b

No association studies

15

TAC1

Target of mir-206, axonal and synaptic transmission

No association studies. Down-regulated in psychosis [40]

16

ATXN1

Interacts with ZNF804A and AKT1

Positive association [18]

17

SYN1

Related to SYN2

No association studies. Associated with epilepsy [41]

18

RTN4IP1

Interacts with RTN4R, neurite growth

No association studies

19

CDKN1A

Interacts with AKT1, target of mir-20b

No association studies

20

LINGO1

Interacts with RTN4R, axonogenesis, CNS development

No association studies. Associated with essential tremor and Parkinson's disease [42]


BioGraph top inferred genes for schizophrenia that are not known as direct relations in the integrated network. Prioritizations are based on a data freeze of September 2009 to retrospectively verify predictions in more recent literature. CNS, central nervous system.

Liekens et al. Genome Biology 2011 12:R57   doi:10.1186/gb-2011-12-6-r57

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