Additional file 6.
Supplementary Figure S5. Functional features (COGs) that are discrimantive for the comparison between adult and infant microbiomes according to Metastats but not detected by LEfSe. Even if median and variance suggest the differences to be discriminative, there are always some microbiomes (at least two) that are overlapping between classes. This is due to the stringent α-value (0.01) set for the KW test in LEfSe and to the fact that we use non-parametric statistics (differently from Metastats). Notice, however, that even using a low α-value LEfSe detects many more biomarkers than metastats (366 versus 192).
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Segata et al. Genome Biology 2011 12:R60 doi:10.1186/gb-2011-12-6-r60