Figure 3.

Role of Atg8 proteins in intracellular trafficking processes. (a) The GABARAP subfamily members GABARAP (GB) and GABARAP-L1 (GB1) participate in the transport of plasma membrane proteins, such as the GABA(A), κ-opioid and transferrin receptors, from the Golgi to the plasma membrane (PM). (b) The GABARAP and the GATE-16 subfamilies both participate in transport from the ER to the Golgi and within the Golgi apparatus. GABARAP, together with PX-RICS, participates in N-cadherin/β-catenin transport from the ER to the Golgi. GATE-16 has been implicated in intra-Golgi transport through its interaction with Golgi SNARE protein 28 (GOS-28). Both subfamilies can interact with NSF, suggesting that they participate in regulation of membrane fusion events.