Open Access Research

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

Gerard Manning1*, David S Reiner234, Tineke Lauwaet2, Michael Dacre1, Alias Smith2, Yufeng Zhai1, Staffan Svard5 and Frances D Gillin2

Author Affiliations

1 Razavi Newman Center for Bioinformatics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

2 Department of Pathology, University of California at San Diego, 214 Dickinson St CTF-C 415, San Diego, CA 92103-8416, USA

3 Department of Microbiology, Tumor and Cell Biology (MTC), Nobels väg 16, KI Solna Campus, Karolinska Institutet, Box 280, SE-171 77, Stockholm, Sweden

4 Current address: Proveri Inc., 10835 Road to the Cure, Suite 150, San Diego, CA 92121, USA

5 Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, SE-75124, Uppsala, Sweden

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Genome Biology 2011, 12:R66  doi:10.1186/gb-2011-12-7-r66

Published: 25 July 2011

Additional files

Additional file 1:

Table S1. Detailed annotation of all kinases in all three strains, including sequences, SAGE expression, classification, and catalytic ability.

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Additional file 2:

Text S1. Supplemental methods and notes.

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Additional file 3:

Table S2. Draft kinomes of Trichomonas vaginalis and Leishmania major.

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Additional file 4:

Table S3. Definition of domain names and abbreviations.

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Additional file 5:

Figure S4. Nek kinase tree, colored and annotated.

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Additional file 6:

Alignment S1. Nek kinase domain alignment.

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Additional file 7:

Figure S1. Logo alignment comparing patterns of conserved residues in Giardia and non-Giardia Neks.

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Additional file 8:

Figure S2. Tree of Nek kinases showing gains and losses between strains.

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Additional file 9:

Figure S3. Logo alignment comparing patterns of conserved residues in Giardia TALM-ankyrin repeats and human ankyrin repeats.

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