Research
The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology
1 Razavi Newman Center for Bioinformatics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
2 Department of Pathology, University of California at San Diego, 214 Dickinson St CTF-C 415, San Diego, CA 92103-8416, USA
3 Department of Microbiology, Tumor and Cell Biology (MTC), Nobels väg 16, KI Solna Campus, Karolinska Institutet, Box 280, SE-171 77, Stockholm, Sweden
4 Current address: Proveri Inc., 10835 Road to the Cure, Suite 150, San Diego, CA 92121, USA
5 Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, SE-75124, Uppsala, Sweden
Genome Biology 2011, 12:R66 doi:10.1186/gb-2011-12-7-r66
Published: 25 July 2011Additional files
Additional file 1:
Table S1. Detailed annotation of all kinases in all three strains, including sequences, SAGE expression, classification, and catalytic ability.
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Additional file 2:
Text S1. Supplemental methods and notes.
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Additional file 3:
Table S2. Draft kinomes of Trichomonas vaginalis and Leishmania major.
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Additional file 4:
Table S3. Definition of domain names and abbreviations.
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Additional file 5:
Figure S4. Nek kinase tree, colored and annotated.
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Additional file 7:
Figure S1. Logo alignment comparing patterns of conserved residues in Giardia and non-Giardia Neks.
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Additional file 8:
Figure S2. Tree of Nek kinases showing gains and losses between strains.
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Additional file 9:
Figure S3. Logo alignment comparing patterns of conserved residues in Giardia TALM-ankyrin repeats and human ankyrin repeats.
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