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Highly Accessed Opinion

The real cost of sequencing: higher than you think!

Andrea Sboner12, Xinmeng Jasmine Mu1, Dov Greenbaum12345, Raymond K Auerbach1 and Mark B Gerstein126*

Author Affiliations

1 Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA

2 Department of Molecular Biology and Biophysics, Yale University, New Haven, CT 06520, USA

3 Sanford T Colb & Co. Intellectual Property Law, 4 Shaar Hagai, Marmorek, Rehovot, 76122, Israel

4 Center for Law and the Biosciences, Stanford Law School, Stanford University, Stanford, CA 94305, USA

5 Sholar in Residence Center for Health Law, Bioethics and Health Policy Kiryat Ono College, 55000, Isreal

6 Department of Computer Science, Yale University, New Haven, CT 06520, USA

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Genome Biology 2011, 12:125  doi:10.1186/gb-2011-12-8-125

Published: 25 August 2011

Abstract

Advances in sequencing technology have led to a sharp decrease in the cost of 'data generation'. But is this sufficient to ensure cost-effective and efficient 'knowledge generation'?

Keywords:
Bioinformatics; costs of sequencing; data analysis; experimental design; next-generation sequencing; sample collection