Table 2

The pathways statistically significant in the 3% most increased transcripts in PPARδ agonist-treated cells identified in the multivariate models

P-value

Pathway

Transcripts increased in PPARδ agonist-treated cells mapping to the pathway


6.3e-08

Glucose regulation of insulin secretion

Cycs, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Ndufb9, Atp5a1, Ndufb5, Gpi1, Tpi1, Pgk1, mt-Co2, Sdhb, Sdhd, mt-Atp6, Cox7b, Ndufb2

1.3e-06

Integration of energy metabolism

Cycs, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Ndufb9, Atp5a1, Cpt2, Ndufb5, Gpi1, Tpi1, Pgk1, mt-Co2, Sdhb, Sdhd, mt-Atp6, Cox7b, Ndufb2

1.3e-06

Diabetes pathways

Hspa8, Cycs, Wdr89, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Myo5a, Ndufb9, Atp5a1, Rps21, Rps3a, Sec11c, Ndufb5, Gpi1, Tpi1, Pgk1, Sdhb, mt-Co2, Dnajb9, Sdhd, mt-Atp6, Cox7b, 2900062L11Rik, Ndufb2

8.5e-06

Electron transport chain

Cycs, Ndufb5, Etfa, mt-Co2, Ndufb10, Sdhb, Sdhd, Ndufb9, Cox7b, Ndufb2

7.1e-04

Citric acid cycle (TCA cycle)

Dld, Sdhb, Sdhd, Mdh2

1.4e-03

Mitochondrial fatty acid β-oxidation of saturated and unsaturated fatty acids

Hadhb, Acadl, Acadvl

1.6e-03

Glycolysis

Aldoa, Tpi1, Pgk1, Gpi1

4.5e-03

Metabolism of lipids and lipoproteins

Agpat3, Hadhb, Ppp1cc, Slc27a1, Lass2, Angptl4, Cpt2, Akr1b3, Abcd3, Acadl, Sgpl1, Acaa2, Acadvl, Mod1, Hmgcs2, Adfp

7.8e-03

Formation of acetoacetic acid in synthesis of ketone bodies

Hmgcs2, Acaa2


Transcripts in bold were increased in both PPARδ and PPARγ agonist-treated cells.

Roberts et al. Genome Biology 2011 12:R75   doi:10.1186/gb-2011-12-8-r75

Open Data