Table 3

The pathways statistically significant in the 3% most increased transcripts in PPARγ agonist-treated cells identified in the multivariate models

P-value

Pathway

Transcripts increased in PPARγ agonist-treated cells mapping to the pathway

6.4e-05

Glycolysis

Aldoa, Pgam1, Pfkl, Gapdh, Gpi1

1.1e-03

Gluconeogenesis

Aldoa, Slc25a11, Pgam1, Gapdh, Gpi1

1.2e-03

Ca²⁺ signaling via IP3 binding to the IP3 receptor, opening the endoplasmic reticulum Ca²⁺ channel

Itpr2, Itpr1

1.8e-03

Phospholipase C-mediated signaling events

Prkaca, Itpr2, Itpr1, Adcy6, Pde1b

2.5e-03

Hormone-sensitive lipase-mediated triacylglycerol hydrolysis

Prkaca, Abhd5, Ppp1ca

2.6e-03

Metabolism of lipids and lipoproteins

Prkaca, Abhd5, Abcd3, Ppp1ca, Ncor1, Chd9, Slc27a1, Hsd17b4, Acaa2, Sin3b, Scd2, Hmgcl, Fads3, Csnk1g2, Angptl4

3.2e-03

Regulation of insulin secretion

Prkaca, Dlst, Ndufb6, Itpr1, Gpi1, Aldoa, Ndufs6, Pgam1, Itpr2, Pfkl, Gapdh

5.8e-03

Formation of acetoacetic acid in the synthesis of ketone bodies

Hmgcl, Acaa2

8.2e-03

Additional metabolism of carbohydrates

Aldoa, Slc25a11, Pgam1, Pfkl, Gapdh, Gpi1, G6pdx

1.1e-02

Protein kinase A-mediated events

Prkaca, Pde1b

1.1e-02

Regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha

Sin3b, Scd2, Fads3, Ncor1, Chd9, Slc27a1, Angptl4

1.7e-02

Integration of energy metabolism

Prkaca, Dlst, Ndufb6, Gpi1, Aldoa, Ndufs6, Pgam1, Pfkl, Adcy6, Gapdh

2.0e-02

β-Oxidation of very long chain fatty acids

Abcd3, Hsd17b4

0.1e-02

Peroxisomal lipid metabolism

Abcd3, Slc27a1, Hsd17b4

Transcripts in bold were increased in both PPARδ and PPARγ agonist-treated cells.

Roberts et al. Genome Biology 2011 12:R75   doi:10.1186/gb-2011-12-8-r75