This article is part of a special issue on exome sequencing, and has been made free to access thanks to support from Roche Nimblegen.
The promise and limitations of population exomics for human evolution studies
1 Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Box 355065, Seattle, WA 98195-5065, USA
2 Department of Pediatrics, University of Washington, 1959 NE Pacific St, Box 356320, Seattle, WA 98195-6320, USA
Genome Biology 2011, 12:127 doi:10.1186/gb-2011-12-9-127Published: 14 September 2011
Exome sequencing is poised to yield substantial insights into human genetic variation and evolutionary history, but there are significant challenges to overcome before this becomes a reality.