Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Roche logoThis article is part of a special issue on exome sequencing, and has been made free to access thanks to support from Roche Nimblegen.

Highly Accessed Opinion

The promise and limitations of population exomics for human evolution studies

Jacob A Tennessen1, Timothy D O'Connor1, Michael J Bamshad12 and Joshua M Akey1*

Author Affiliations

1 Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Box 355065, Seattle, WA 98195-5065, USA

2 Department of Pediatrics, University of Washington, 1959 NE Pacific St, Box 356320, Seattle, WA 98195-6320, USA

For all author emails, please log on.

Genome Biology 2011, 12:127  doi:10.1186/gb-2011-12-9-127

Published: 14 September 2011

Abstract

Exome sequencing is poised to yield substantial insights into human genetic variation and evolutionary history, but there are significant challenges to overcome before this becomes a reality.