This article is part of a special issue on exome sequencing, and has been made free to access thanks to support from Roche Nimblegen.
Exome sequencing: the expert view
1 Genetic Disease Research Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
2 Genome Analysis Facility, Duke Center for Human Genome Variation, Duke University School of Medicine, B342E LSRC Bldg, Durham, NC 27710, USA
3 NIH Intramural Sequencing Center and Comparative Genomics Unit, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Genome Biology 2011, 12:128 doi:10.1186/gb-2011-12-9-128Published: 14 September 2011
To complement our special issue on exome sequencing, Genome Biology asked several leaders in the field for their views on this new approach. Leslie G Biesecker (LGB), Jim C Mullikin (JM) and Kevin V Shianna (KVS) discuss the reasons for the popularity of exome sequencing and its contribution to genomics.