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Roche logoThis article is part of a special issue on exome sequencing, and has been made free to access thanks to support from Roche Nimblegen.

Highly Accessed Opinion

Exome sequencing: the expert view

Leslie G Biesecker1*, Kevin V Shianna2 and Jim C Mullikin3

Author Affiliations

1 Genetic Disease Research Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

2 Genome Analysis Facility, Duke Center for Human Genome Variation, Duke University School of Medicine, B342E LSRC Bldg, Durham, NC 27710, USA

3 NIH Intramural Sequencing Center and Comparative Genomics Unit, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

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Genome Biology 2011, 12:128  doi:10.1186/gb-2011-12-9-128

Published: 14 September 2011

Abstract

To complement our special issue on exome sequencing, Genome Biology asked several leaders in the field for their views on this new approach. Leslie G Biesecker (LGB), Jim C Mullikin (JM) and Kevin V Shianna (KVS) discuss the reasons for the popularity of exome sequencing and its contribution to genomics.