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This article is part of a special issue on exome sequencing.

Open Access Research

Expanding whole exome resequencing into non-human primates

Eric J Vallender

Author Affiliations

New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA

Genome Biology 2011, 12:R87  doi:10.1186/gb-2011-12-9-r87

Published: 14 September 2011

Additional files

Additional file 1:

Additional Figure 1 - exonic coverage across species. Percent coverage of coding exons are binned and presented as a histogram. (a-c) Coverage percentages are based on alignments between human (a), chimpanzee (b), and rhesus macaque (c) and the human genome (hg18) with gene sequences defined by RefSeq annotations.

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Open Data

Additional file 2:

Additional Figure 2 - chromosomal distribution of coverage failure. Percent of coding exons without any coverage by chromosomal position. Y chromosome exons are consistently and substantially more likely to show no coverage compared to autosomal exons. X chromosome exons are also more likely to show no coverage though to a lesser extent. Both trends hold across species.

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Open Data