This article is part of a special issue on exome sequencing.

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Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families

Zippora Brownstein1, Lilach M Friedman1, Hashem Shahin2, Varda Oron-Karni3, Nitzan Kol3, Amal Abu Rayyan2, Thomas Parzefall1, Dorit Lev4, Stavit Shalev56, Moshe Frydman7, Bella Davidov8, Mordechai Shohat18, Michele Rahile9, Sari Lieberman10, Ephrat Levy-Lahad1011, Ming K Lee12, Noam Shomron133, Mary-Claire King12, Tom Walsh12, Moien Kanaan2 and Karen B Avraham13*

Author Affiliations

1 Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

2 Department of Biological Sciences, Bethlehem University, Bethlehem, Palestinian Authority

3 Genome High-Throughput Sequencing Laboratory, Tel Aviv University, Tel Aviv 69978, Israel

4 Institute of Medical Genetics, Wolfson Medical Center, Holon 58100, Israel

5 Genetics Institute, Ha'Emek Medical Center, Afula 18341, Israel

6 Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 32000, Israel

7 Danek Gartner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer 52621, Israel

8 Department of Medical Genetics, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel

9 Darr Al Kalima Audiological Clinic, Bethlehem, Palestinian Authority

10 Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel

11 Hebrew University Medical School, Jerusalem 91120, Israel

12 Department of Medicine (Medical Genetics) and Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA

13 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Genome Biology 2011, 12:R89  doi:10.1186/gb-2011-12-9-r89

Published: 14 September 2011

Additional files

Additional file 1:

Table of human genes captured.

Format: XLS Size: 144KB Download file

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Additional file 2:

Table of captured sequences.

Format: XLS Size: 421KB Download file

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Additional file 3:

Tables of indels and SNPs in four or more probands in our population. (a) Table of indels appearing in four or more probands in our population (n = 11). (b) Table of SNPs in four or more probands in our population (n = 11).

Format: XLS Size: 119KB Download file

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Additional file 4:

Table of primers and restriction enzyme digestion assays.

Format: XLS Size: 31KB Download file

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