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Co-survival of the fittest few: mosaic amplification of receptor tyrosine kinases in glioblastoma

Feng Chen1 and Li Ding23*

Author Affiliations

1 Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA

2 The Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA

3 Department of Genetics, Washington University School of Medicine, St Louis, MO 63108, USA

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Genome Biology 2012, 13:141 doi:10.1186/gb-2012-13-1-141

Published: 30 January 2012

Abstract

Mosaic amplification of receptor tyrosine kinases in glioblastoma suggests that tumor cells with different progression driver mutations may coevolve rather than compete during clonal evolution.

Keywords:
Clonal evolution; tumor heterogeneity; glioblastoma; mosaic amplification; receptor tyrosine kinases; progression driver mutations