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Highly Accessed Opinion

What is complex about complex disorders?

Kevin J Mitchell

Author Affiliations

Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland

Genome Biology 2012, 13:237  doi:10.1186/gb-2012-13-1-237

Published: 23 January 2012

Abstract

Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes.