Transcriptional enhancers in development and disease
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Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Genome Biology 2012, 13:238 doi:10.1186/gb-2012-13-1-238Published: 23 January 2012
Distal transcription enhancers are cis-regulatory elements that promote gene expression, enabling spatiotemporal control of genetic programs such as those required in metazoan developmental processes. Because of their importance, their disruption can lead to disease.