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Genetic adaptation to high altitude in the Ethiopian highlands

Laura B Scheinfeldt1, Sameer Soi1, Simon Thompson1, Alessia Ranciaro1, Dawit Woldemeskel2, William Beggs1, Charla Lambert13, Joseph P Jarvis1, Dawit Abate2, Gurja Belay2 and Sarah A Tishkoff14*

Author Affiliations

1 Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA

2 Department of Biology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia

3 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA

4 Department of Biology, University of Pennsylvania, 433 S. University Avenue, Philadelphia, PA 19104, USA

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Genome Biology 2012, 13:R1  doi:10.1186/gb-2012-13-1-r1

Published: 20 January 2012

Additional files

Additional file 1:

Supplementary Tables S1 to S8. Given their length, we are providing Supplementary Tables S1 to S8 as a separate.xls file containing eight sheets, one for each table.

Format: XLS Size: 532KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Figure S1 - hemoglobin levels associated with THRB (RS826216) genotypes. The three THRB genotypes along the x-axis and the corresponding hemoglobin levels along the y-axis. The C/C gentoype sample size = 10, the C/T genotype sample size = 17, and the T/T genotype sample size = 15.

Format: PNG Size: 5KB Download file

Open Data

Additional file 3:

Figure S2 - extended haplotype patterns at CBARA1. Phased haplotypes at the CBARA1 locus for all individuals (above) and for the Omotic and Amhara individuals clustered separately (below). The chromosomal position is displayed along the x-axis and each haplotype is displayed along the y-axis.

Format: PNG Size: 27KB Download file

Open Data

Additional file 4:

Figure S3 - map of the field sites. A map of Ethiopia with each of the three field sites marked with a grey dot.

Format: PDF Size: 6KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Figure S4 - histogram of FST values genome-wide. The x-axis displays the binned FST values and the y-axis displays the number of SNPs that fall in the bin.

Format: PNG Size: 5KB Download file

Open Data

Additional file 6:

Figure S5 - histogram of Amhara LSBL values genome-wide. The x-axis displays the binned LSBL values and the y-axis displays the number of SNPs that fall in the bin.

Format: PNG Size: 5KB Download file

Open Data

Additional file 7:

Figure S6 - histogram of iHS values genome-wide. The x-axis displays the binned iHS values and the y-axis displays the number of SNPs that fall in the bin.

Format: PNG Size: 4KB Download file

Open Data

Additional file 8:

Figure S7 - histogram of XP-CLR values genome-wide. The x-axis displays the binned XP-CLR values and the y-axis displays the number of SNPs that fall in the bin.

Format: PNG Size: 5KB Download file

Open Data