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Open Access Method

Uberon, an integrative multi-species anatomy ontology

Christopher J Mungall1*, Carlo Torniai2, Georgios V Gkoutos3, Suzanna E Lewis1 and Melissa A Haendel2

Author Affiliations

1 Genomics Division, Lawrence Berkeley National Laboratory, 1 Cycltotron Road MS 64-121, Berkeley, CA 94720, USA

2 Library and Department of Medical Informatics and Clinical Epidemiology Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA

3 Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK

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Genome Biology 2012, 13:R5  doi:10.1186/gb-2012-13-1-r5

Published: 31 January 2012

Abstract

We present Uberon, an integrated cross-species ontology consisting of over 6,500 classes representing a variety of anatomical entities, organized according to traditional anatomical classification criteria. The ontology represents structures in a species-neutral way and includes extensive associations to existing species-centric anatomical ontologies, allowing integration of model organism and human data. Uberon provides a necessary bridge between anatomical structures in different taxa for cross-species inference. It uses novel methods for representing taxonomic variation, and has proved to be essential for translational phenotype analyses. Uberon is available at http://uberon.org webcite