Enzymes predicted to have similar metabolic impact to that of isoniazid targets. Shown are the enzymes in the combined model identified to be in an enzyme subset with the targets of isoniazid, as well as the reactions for which these enzymes are essential. Circles indicate metabolites; squares indicate reactions; octagons indicate enzymes. The subnetwork was laid out with Cytoscape  and several currency metabolites were removed.
Chindelevitch et al. Genome Biology 2012 13:r6 doi:10.1186/gb-2012-13-1-r6