DNA methylation studies using twins: what are they telling us?
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Genome Biology 2012, 13:172 doi:10.1186/gb-2012-13-10-172Published: 18 October 2012
Recent studies have identified both heritable DNA methylation effects and differential methylation in disease-discordant identical twins. Larger sample sizes, replication, genetic-epigenetic analyses and longitudinal assays are now needed to establish the role of epigenetic variants in disease.