Opinion
DNA methylation studies using twins: what are they telling us?
Author affiliations
Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas Hospital Campus, Westminster Bridge Road, London, SE1 7EH, UK
Citation and License
Genome Biology 2012, 13:172 doi:10.1186/gb-2012-13-10-172
Published: 18 October 2012Abstract
Recent studies have identified both heritable DNA methylation effects and differential methylation in disease-discordant identical twins. Larger sample sizes, replication, genetic-epigenetic analyses and longitudinal assays are now needed to establish the role of epigenetic variants in disease.
