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This article is part of a special issue on epigenomics.

Highly Accessed Research highlight

Balance of DNA methylation and demethylation in cancer development

Chun-Xiao Song and Chuan He*

Author Affiliations

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA

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Genome Biology 2012, 13:173  doi:10.1186/gb-2012-13-10-173

Published: 23 October 2012

Abstract

Genome-wide 5-hydroxymethylome analysis of a rodent hepatocarcinogen model reveals that 5-hydroxymethylcytosine-dependent active DNA demethylation may be functionally important in the early stages of carcinogenesis.

See research article http://genomebiology.com/2012/13/10/R93 webcite