Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

This article is part of a special issue on epigenomics.

Highly Accessed Research highlight

Balance of DNA methylation and demethylation in cancer development

Chun-Xiao Song and Chuan He*

Author affiliations

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA

For all author emails, please log on.

Citation and License

Genome Biology 2012, 13:173  doi:10.1186/gb-2012-13-10-173

Published: 23 October 2012

Abstract

Genome-wide 5-hydroxymethylome analysis of a rodent hepatocarcinogen model reveals that 5-hydroxymethylcytosine-dependent active DNA demethylation may be functionally important in the early stages of carcinogenesis.

See research article http://genomebiology.com/2012/13/10/R93 webcite