The birth of the Epitranscriptome: deciphering the function of RNA modifications
1 Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA
2 The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10065, USA
3 Tri-Institutional Training Program in Computational Biology and Medicine, New York, NY10065, USA
4 Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
5 Pacific Biosciences, 1380 Willow Rd, Menlo Park, CA 94025, USA
Genome Biology 2012, 13:175 doi:10.1186/gb-2012-13-10-175Published: 31 October 2012
Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.