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Highly Accessed Review

Surveying the epigenomic landscape, one base at a time

Gabriel E Zentner1 and Steven Henikoff12*

Author Affiliations

1 Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USA

2 Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USA

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Genome Biology 2012, 13:250 doi:10.1186/gb-2012-13-10-250

Published: 22 October 2012

Abstract

Epigenomics, the determination of epigenetic landscapes on a genome-wide scale, has progressed at an astounding rate over the past decade. Recent technological developments have enabled base-pair resolution of various epigenomic features, leading to new insights into epigenetic regulation.

Keywords:
epigenomics; chromatin immunoprecipitation; ChIP-exo; micrococcal nuclease mapping; deoxyribonuclease I mapping