This article is part of a special issue on epigenomics.
What can epigenomics do for you?
Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
Genome Biology 2012, 13:420 doi:10.1186/gb-2012-13-10-420Published: 23 October 2012
First paragraph (this article has no abstract)
In 1990, with the initial launch of a 15-year project to map and sequence the human genome, a new era of science began. However, even after its successful and early completion in 2001 , no one could have foreseen how, only a few years later, genome sequencing would explode to become a widely applied multi-purpose tool whose applications include the mapping of epigenetic modifications and the complete assessment of both coding and non-coding RNA transcripts. The game changer behind this explosion was the transition from the classic electrophoretic Sanger sequencing method, which had limited scalability, to image-based massively parallel 'sequencing-by-synthesis' platforms.