This article is part of a special issue on epigenomics.

Open Access Research

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

Duncan Sproul12, Robert R Kitchen13, Colm E Nestor12, J Michael Dixon1, Andrew H Sims1, David J Harrison14, Bernard H Ramsahoye15 and Richard R Meehan12*

Author Affiliations

1 Breakthrough Breast Cancer Research Unit and Division of Pathology, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK

2 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK

3 Yale University School of Medicine, Department of Molecular Biophysics & Biochemistry and Department of Psychiatry, 266 Whitney Ave, New Haven, CT 06511, USA

4 University of St Andrews School of Medicine, Medical and Biological Sciences Building, University of St Andrews, North Haugh, St Andrews KY16 9TF, UK

5 Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK

For all author emails, please log on.

Genome Biology 2012, 13:R84  doi:10.1186/gb-2012-13-10-r84

Published: 3 October 2012

Additional files

Additional file 1:

1,009 hypermethylation prone genes. Excel file containing details of the 1,009 hypermethylation prone genes in the 7 cancer types.

Format: XLS Size: 229KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Supplementary data. PDF file containing four supplementary figures, one table and their legends.

Format: PDF Size: 1.6MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

446 variably methylated genes. Excel file containing details of the 446 variably hypermethylated genes along with their susceptibility in the different cancer types.

Format: XLS Size: 116KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

220 consistently methylated genes. Excel file containing details of the 220 consistently hypermethylated genes in the 7 different types of cancer.

Format: XLS Size: 40KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data