Research
Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity
- † Equal contributors
1 Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA
2 Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94115, USA
3 Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
4 Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
5 Department of Urology, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
6 Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA
7 Department of Computer Science, Duke University, Durham, NC 27708, USA
8 Departments of Biology and Genetics, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
9 Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27708, USA
10 Department of Medicine, University of California at San Francisco School of Medicine, San Francisco, CA 94115, USA
11 Department of Urology, University of California at San Francisco School of Medicine, San Francisco, CA 94115, USA
Genome Biology 2012, 13:R88 doi:10.1186/gb-2012-13-10-r88
Published: 3 October 2012Additional files
Additional file 1:
Supplemental information containing four supplemental figures and three supplemental tables.
Format: PDF Size: 4.4MB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2:
Table S4 detailing RefSeq genes identified as differentially expressed in response to androgen receptor activation by mRNA-seq. mRNA from three biological replicates of LNCaP and three biological replicates of LNCaP-induced was extracted and sequenced. Genes differentially regulated by AR activation were determined using edgeR at a threshold of FDR < 0.05.
Format: XLSX Size: 43KB Download file
Additional file 3:
Table S5 showing a comparison of androgen receptor-regulated genes as determined by mRNA-seq to previously published androgen receptor-regulated gene lists. Genes identified as differentially regulated by AR activation are shown along with all other RefSeq genes, ranked in order by the number of published studies that identify the gene as AR-regulated.
Format: XLSX Size: 1MB Download file
