Identification of DNase I hypersensitive sites in LNCaP cells before and after R1881 stimulation. (a) DNase-seq signal is a continuous signal across the genome. We illustrate the chromatin accessibility around the KLK locus before and after hormone induction. Each sample has a fixed y-axis DNase-seq score of 0.7. (b) Overlap between DHS sites identified before and after hormone as compared to the unrelated cell line HepG2. (c) Spearman correlation heatmap of the union set of top 100,000 DHS peaks in each of the nine cell lines illustrated. (d) Distribution of all DHS sites relative to genic elements. DHS: DNase I hypersensitive; DNase-seq: DNase I hypersensitivity analysis coupled with high-throughput sequencing; kb; kilobase pairs; TSS: transcription start site.
Tewari et al. Genome Biology 2012 13:R88 doi:10.1186/gb-2012-13-10-r88