Identification of differences in DNase-seq signal. (a) Top panel: distribution of tags per ΔDNase windows in LNCaP versus LNCaP-induced. Bottom panel: distribution of DNase-seq tags in union regions used to identify ΔDNase increases and decreases. (b) Distribution of ΔDNase regions and all union (of LNCaP and LNCaP-induced) DHS regions relative to genic elements. (c) Replicates of DNase-seq data around KLK3 and KLK2. Y-axis is fixed to range from 0 to 0.4 for all rows. Highlighted regions marked by an asterisk represent examples of significant ΔDNase increases. (d) Significant motifs identified de novo in ΔDNase gain and loss regions. DHS: DNase I hypersensitive; DNase-seq: DNase I hypersensitivity analysis coupled with high-throughput sequencing; kb; kilobase pairs; TSS: transcription start site.
Tewari et al. Genome Biology 2012 13:R88 doi:10.1186/gb-2012-13-10-r88