Table 2 |
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|
Lack of spreading of DNA methylation from ERV copies into gene transcription start sites |
||||||||
|
ERV ID |
Family |
Type |
Gene |
Distance to TSS (bp) |
% ERV methylation |
% Gene promoter methylation |
CGI promoter? |
Tissue studied |
|
|
||||||||
|
1027 |
ETn/MusD |
Solo |
Eef1e1 |
1266 |
MeDIP (see Table S1) |
1.4 |
Yes |
Spleen |
|
2374 |
IAP |
Full length |
Gng10 |
2119 |
92 |
1 |
Yes |
Spleen |
|
3893 |
ETn/MusD |
Full length |
Mthfd2l |
754 |
80* |
0* |
Yes |
ES cells, embryo, brain |
|
ti1080339794 |
IAP |
Full length |
Gdpd3 |
437 |
75.7 |
0 |
No |
ES cells |
|
4305 |
IAP |
Solo |
Hus1 |
1515 |
86 |
1 |
Yes |
ES cells |
|
8545 |
IAP |
Full length |
Pnpt1 |
973 |
95a |
1* |
Yes |
ES cells, thymus |
|
9963 |
IAP |
Full length |
Atxn1l |
1316 |
97 |
0 |
Yes |
Brain, liver |
|
ti1072970530 |
IAP |
Solo |
B3galtl |
368 |
84.1 |
1.4 |
Yes |
Brain |
|
ti1102177987 |
IAP |
Full length |
Eps15 |
1613 |
97.2 |
1 |
Yes |
Brain |
|
|
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|
*Average of tissues studied. bp: base pairs; CGI: CpG Island; ERV: endogenous retrovirus; ES: embryonic stem; ETn/MusD: Early transposon/Mus musculus type D; IAP: Intracisternal (A) Particle; TSS: transcription start site. |
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|
Rebollo et al. Genome Biology 2012 13:R89 doi:10.1186/gb-2012-13-10-r89 |
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