Direct connection gene sub-networks for the top 10% interconnected genes from each module of the separate networks for female and male obtained by global literature analysis. (a) Female; (b) male. Directly connected genes only are shown according to their location in the cell (on the membrane, in the Golgi apparatus, nucleus, or cytoplasm or outside the cell). Node shapes: oval and circle, protein; diamond, ligand; circle/oval on tripod platform, transcription factor; ice cream cone, receptor; crescent, kinase or protein kinase; irregular polygon, phosphatase. Color code: red, up-regulated genes; blue, down-regulated genes. Arrows with a plus sign indicate positive regulation/activation; arrows with a minus sign indicate negative regulation/inhibition; grey arrows represent regulation; lilac arrows represent expression; purple arrows represent binding; green arrows represent promoter binding; yellow arrows represent protein modification.
Skinner et al. Genome Biology 2012 13:R91 doi:10.1186/gb-2012-13-10-r91