Table 1

Pathway enrichment for 11 male and female rat tissue signature lists

11 male and female tissues

Sex and tissue


Male

Female



6 tissues

Heart

Kidney

Liver

Prostate

SV

Testis

5 tissues

Heart

Kidney

Liver

Ovary

Uterus


Pathway name

Number of genes in input list

4059

3046

172

725

266

1112

274

552

1298

408

151

99

305

279

Total number of affected pathways

230

224

79

151

141

191

90

99

191

108

79

29

80

138

Pathways in cancer

45

32

3

7

6

13

1

2

17

6

3

1

3

4

Protein processing in endoplasmic reticulum

39

38

3

4

1

22

5

4

3

1

1

1

HTLV-I infection

39

31

8

3

14

3

2

10

4

2

1

3

RNA transport

39

31

1

8

17

3

6

11

4

1

2

4

Transcriptional misregulation in cancers

31

26

1

8

6

7

4

3

12

6

3

1

3

Herpes simplex infection

30

23

2

10

3

7

2

1

9

3

1

2

3

Lysosome

29

27

1

5

4

16

2

2

5

1

1

3

Ribosome

29

27

2

5

1

20

4

1

1

2

Endocytosis

29

26

1

4

8

11

1

3

5

2

3

Phagosome

28

27

1

6

6

12

2

7

3

4

MAPK signaling pathway

28

21

1

7

3

7

1

2

8

3

1

4

Spliceosome

27

17

8

1

1

2

7

12

6

1

1

5

Regulation of actin cytoskeleton

26

24

1

6

6

9

3

5

3

1

1

Alzheimer's disease

26

22

2

4

7

10

5

2

3

Huntington's disease

26

22

1

6

2

14

5

1

1

2

1

Purine metabolism

26

22

1

6

2

4

2

6

7

2

5

Focal adhesion

26

21

2

2

7

8

3

9

3

2

4

Chemokine signaling pathway

24

23

3

4

6

9

1

1

4

2

2

Pyrimidine metabolism

24

20

1

6

1

6

1

5

6

1

1

1

3

Tuberculosis

24

20

6

6

9

1

9

1

1

7

Influenza A

23

21

1

5

2

11

1

3

5

1

2

2

Oxidative phosphorylation

23

20

1

4

5

11

5

1

1

3

Leukocyte transendothelial migration

22

18

2

1

7

8

1

6

4

1

1

Cytokine-cytokine receptor interaction

21

19

1

6

7

6

4

3

1

Osteoclast differentiation

21

18

1

2

6

10

1

5

1

1

3

Cell adhesion molecules

20

14

2

3

4

6

1

7

3

1

1

2

Insulin signaling pathway

19

13

2

3

6

2

6

2

4

mRNA surveillance pathway

19

13

1

4

5

2

4

8

4

2

2


HTLV, human T-lymphotropic virus; MAPK, mitogen-activated protein kinase; SV, seminal vesicle.

Skinner et al. Genome Biology 2012 13:R91   doi:10.1186/gb-2012-13-10-r91

Open Data