Table 1 |
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|
Pathway enrichment for 11 male and female rat tissue signature lists |
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|
11 male and female tissues |
Sex and tissue |
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|
|
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|
Male |
Female |
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|
|
|
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|
6 tissues |
Heart |
Kidney |
Liver |
Prostate |
SV |
Testis |
5 tissues |
Heart |
Kidney |
Liver |
Ovary |
Uterus |
||
|
|
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|
Pathway name |
||||||||||||||
|
Number of genes in input list |
4059 |
3046 |
172 |
725 |
266 |
1112 |
274 |
552 |
1298 |
408 |
151 |
99 |
305 |
279 |
|
Total number of affected pathways |
230 |
224 |
79 |
151 |
141 |
191 |
90 |
99 |
191 |
108 |
79 |
29 |
80 |
138 |
|
Pathways in cancer |
45 |
32 |
3 |
7 |
6 |
13 |
1 |
2 |
17 |
6 |
3 |
1 |
3 |
4 |
|
Protein processing in endoplasmic reticulum |
39 |
38 |
3 |
4 |
1 |
22 |
5 |
4 |
3 |
1 |
1 |
1 |
||
|
HTLV-I infection |
39 |
31 |
8 |
3 |
14 |
3 |
2 |
10 |
4 |
2 |
1 |
3 |
||
|
RNA transport |
39 |
31 |
1 |
8 |
17 |
3 |
6 |
11 |
4 |
1 |
2 |
4 |
||
|
Transcriptional misregulation in cancers |
31 |
26 |
1 |
8 |
6 |
7 |
4 |
3 |
12 |
6 |
3 |
1 |
3 |
|
|
Herpes simplex infection |
30 |
23 |
2 |
10 |
3 |
7 |
2 |
1 |
9 |
3 |
1 |
2 |
3 |
|
|
Lysosome |
29 |
27 |
1 |
5 |
4 |
16 |
2 |
2 |
5 |
1 |
1 |
3 |
||
|
Ribosome |
29 |
27 |
2 |
5 |
1 |
20 |
4 |
1 |
1 |
2 |
||||
|
Endocytosis |
29 |
26 |
1 |
4 |
8 |
11 |
1 |
3 |
5 |
2 |
3 |
|||
|
Phagosome |
28 |
27 |
1 |
6 |
6 |
12 |
2 |
7 |
3 |
4 |
||||
|
MAPK signaling pathway |
28 |
21 |
1 |
7 |
3 |
7 |
1 |
2 |
8 |
3 |
1 |
4 |
||
|
Spliceosome |
27 |
17 |
8 |
1 |
1 |
2 |
7 |
12 |
6 |
1 |
1 |
5 |
||
|
Regulation of actin cytoskeleton |
26 |
24 |
1 |
6 |
6 |
9 |
3 |
5 |
3 |
1 |
1 |
|||
|
Alzheimer's disease |
26 |
22 |
2 |
4 |
7 |
10 |
5 |
2 |
3 |
|||||
|
Huntington's disease |
26 |
22 |
1 |
6 |
2 |
14 |
5 |
1 |
1 |
2 |
1 |
|||
|
Purine metabolism |
26 |
22 |
1 |
6 |
2 |
4 |
2 |
6 |
7 |
2 |
5 |
|||
|
Focal adhesion |
26 |
21 |
2 |
2 |
7 |
8 |
3 |
9 |
3 |
2 |
4 |
|||
|
Chemokine signaling pathway |
24 |
23 |
3 |
4 |
6 |
9 |
1 |
1 |
4 |
2 |
2 |
|||
|
Pyrimidine metabolism |
24 |
20 |
1 |
6 |
1 |
6 |
1 |
5 |
6 |
1 |
1 |
1 |
3 |
|
|
Tuberculosis |
24 |
20 |
6 |
6 |
9 |
1 |
9 |
1 |
1 |
7 |
||||
|
Influenza A |
23 |
21 |
1 |
5 |
2 |
11 |
1 |
3 |
5 |
1 |
2 |
2 |
||
|
Oxidative phosphorylation |
23 |
20 |
1 |
4 |
5 |
11 |
5 |
1 |
1 |
3 |
||||
|
Leukocyte transendothelial migration |
22 |
18 |
2 |
1 |
7 |
8 |
1 |
6 |
4 |
1 |
1 |
|||
|
Cytokine-cytokine receptor interaction |
21 |
19 |
1 |
6 |
7 |
6 |
4 |
3 |
1 |
|||||
|
Osteoclast differentiation |
21 |
18 |
1 |
2 |
6 |
10 |
1 |
5 |
1 |
1 |
3 |
|||
|
Cell adhesion molecules |
20 |
14 |
2 |
3 |
4 |
6 |
1 |
7 |
3 |
1 |
1 |
2 |
||
|
Insulin signaling pathway |
19 |
13 |
2 |
3 |
6 |
2 |
6 |
2 |
4 |
|||||
|
mRNA surveillance pathway |
19 |
13 |
1 |
4 |
5 |
2 |
4 |
8 |
4 |
2 |
2 |
|||
|
|
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|
HTLV, human T-lymphotropic virus; MAPK, mitogen-activated protein kinase; SV, seminal vesicle. |
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|
Skinner et al. Genome Biology 2012 13:R91 doi:10.1186/gb-2012-13-10-r91 |
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