Additional file 12.

Figure S10. Genes with 5hmC enrichment over their TSS show some enrichment towards those that are expressed in a tissue-specific manner. The relative levels of tissue specificity were plotted (see Materials and methods; Si value of 0 = non tissue specific, Si value of 6.2 = highly tissue specific) against groups of genes with high tissue specificity as well as housekeeping genes. In comparison to all of the genes on the array there is a small but significant (P-value < 0.001) increase in the level of tissue specificity for genes with 5hmC-enriched regions spanning the TSS. The red lines represent the median score of the group of genes. The upper circles represent outliers of the majority of genes.

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Thomson et al. Genome Biology 2012 13:R93   doi:10.1186/gb-2012-13-10-r93