HIST1H3C has lower mRNA expression levels in NB cell lines in which the HIST1H3C promoter is methylated. Thirty-one NB cell lines were categorized according to their MYCN amplification and HIST1H3C methylation status. The relative HIST1H3C mRNA expression level of each of these cell lines is indicated (MYCN single copy - Unmethylated, MYCN single copy - Methylated; MYCN amplified - Unmethylated, MYCN amplified - Methylated). P-values according to the Mann-Whitney test are also indicated.
Decock et al. Genome Biology 2012 13:R95 doi:10.1186/gb-2012-13-10-r95